Реакция #3663

Уравнение реакции

hydrogen peroxide

ethyl iodoacetate

hydrogen peroxide

1-(2-nitrophenyl)pyrrole

ethyl iodoacetate

→

product

Выход 10.9%

1-(2-Nitrophenyl)-2-pyrroleacetic acid, ethyl ester

Выход 10.9%

Растворители

water

dimethyl sulfoxide

Условия реакции

Обработка

1. 1
   Другоеat room temperature
2. 2
   workup.STIRRINGthe mixture stirred at room temperature for 1 day
3. 3
   Экстракцияextracted with diethyl ether
4. 4
   ЭкстракцияThe organic extract
5. 5
   Промывкаis washed with water, brine
6. 6
   Сушкаdried (Na2SO4)
7. 7
   ДругоеThe solvent is removed
8. 8
   Другоеthe residue (2.12 g) chromatographed on silica gel with ethyl acetate-hexane (1:4) as solvent

Методика

To a stirred mixture of 1.88 g of 1-(2-nitrophenyl)pyrrole, 4.80 g of ethyl iodoacetate and 2.22 g of FeSO4.7H2O in 40 ml of dimethyl sulfoxide is added dropwise 10 ml of 30% hydrogen peroxide while keeping the reaction mixture at room temperature with a cold water bath. The mixture is stirred at room temperature for one day. An additional 2.4 g of ethyl iodoacetate, 1.1 g of FeSO4.7H2O and 5 ml of 30% hydrogen peroxide is added and the mixture stirred at room temperature for 1 day. The mixture is diluted with water and extracted with diethyl ether. The organic extract is washed with water, brine and dried (Na2SO4). The solvent is removed and the residue (2.12 g) chromatographed on silica gel with ethyl acetate-hexane (1:4) as solvent to give 0.30 g of product as a brown gum.

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