Реакция #366147

Уравнение реакции

2-benzyloxy-5-bromo-6-nitro-benzo[de]isoquinoline-1,3-dione

3-methylpiperidine

→

title compound

Выход 86.9%

2-Benzyloxy-5-bromo-6-(3-methyl-piperidin-1-yl)-benzo[de]isoquinoline-1,3-dione

Выход 86.9%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was reacted at 120° C. for 5 hours
2. 2
   Температураcooled
3. 3
   Концентрированиеconcentrated under vacuum
4. 4
   ДругоеThe resulting residue was purified by column chromatography on silica gel

Методика

To a solution of 2-benzyloxy-5-bromo-6-nitro-benzo[de]isoquinoline-1,3-dione (0.50 g, 1.2 mmol, from Example S1-A) in DMF (5 mL) was added 3-methylpiperidine (0.47 g, 4.7 mmol). The reaction was reacted at 120° C. for 5 hours, cooled, and concentrated under vacuum. The resulting residue was purified by column chromatography on silica gel using hexane/ethyl acetate (5:1) to give 0.50 g of the title compound.

Источник