Реакция #3637

Уравнение реакции

2-methylbenzoyl chloride

triethylamine

5,10-dihydro-5-(4-aminobenzoyl)-4H-pyrazolo-[5,1-c][1,4]benzodiazepine

→

desired product

N-[4-(4H-Pyrazolo[5,1-c][1,4]benzodiazepin-5(10H)-ylcarbonyl)phenyl]-2-methylbenzamide

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   Промывкаis then washed with water, NaHCO3, and brine
2. 2
   СушкаThe organic layer is dried with Na2SO4
3. 3
   Фильтрацияfiltered
4. 4
   Другоеevaporated in vacuo
5. 5
   Другоеto give a solid which
6. 6
   Другоеis purified by flash chromatography on silica gel

Методика

To a stirred solution of 3 mmol of 2-methylbenzoyl chloride in 10 ml of methylene chloride is added 5 mmol of triethylamine and 3 mmol of 5,10-dihydro-5-(4-aminobenzoyl)-4H-pyrazolo-[5,1-c][1,4]benzodiazepine. The mixture is stirred at room temperature for 5 hours and is then washed with water, NaHCO3, and brine. The organic layer is dried with Na2SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography on silica gel to give the desired product as a solid, m.p. 142°-146° C.

Источник