Реакция #363439

Уравнение реакции

1-amino-1-(hydroxymethyl)cyclopentane

TFA

cyclohexanone

sodium sulfate

→

14-aza-7-oxadispiro[4.2.5.1]tetradecane

Выход 97.2%

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   Промывкаwas sequentially washed with water (10 mL)
2. 2
   Сушкаa saturated NaHCO3 solution (20 mL), dried (MgSO4)
3. 3
   Концентрированиеconcentrated under reduced pressure

Методика

To a solution of 1-amino-1-(hydroxymethyl)cyclopentane (Method B1c; 1.44 g, 12.54 mmol) in CH2Cl2 (10 mL) at 4° C. was added TFA (0.097 mL, 1.25 mmol), cyclohexanone (1.30 mL, 12.54 mmol) and sodium sulfate (2 g) and the reaction was warmed to 20° C. The reaction was stirred for 72 h and was sequentially washed with water (10 mL) and a saturated NaHCO3 solution (20 mL), dried (MgSO4), and concentrated under reduced pressure to give 14-aza-7-oxadispiro[4.2.5.1]tetradecane (2.38 g, 97%): GC-MS m/z 195 (M+).

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