Реакция #3630

Уравнение реакции

9,10-dihydro-10-(4-nitrobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

ethyl acetate

→

desired product

9,10-Dihydro-10-(4-aminobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

Растворители

ethyl alcohol

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction mixture is filtered through a pad of diatomaceous earth
2. 2
   КонцентрированиеThe filtrate is concentrated in vacuo to a solid which
3. 3
   Другоеis purified by flash chromatography on silica gel

Методика

A mixture of 1 mmol of 9,10-dihydro-10-(4-nitrobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine in 10 ml of ethyl alcohol and 10 ml of ethyl acetate containing 0.2 g of 10% Pd/C is hydrogenated for 5 hours. The reaction mixture is filtered through a pad of diatomaceous earth. The filtrate is concentrated in vacuo to a solid which is purified by flash chromatography on silica gel to give the desired product.

Источник