Реакция #362840

Уравнение реакции

sodium trimethylsilanolate

sodium trimethylsilanolate

ethyl N-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)carbamate

DBU

DBU

sodium hydride

ethyl 3-amino4,4,4-trifluorocrotonate

→

title compound

3-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)-6-trifluoromethyl-2,4-(1H,3H)-pyrimidinedione

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThis compound was prepared

Методика

This compound was prepared using 4.0 grams (0.036 mole) of sodium trimethylsilanolate, 6.6 grams (0.036 mole) of ethyl 3-amino4,4,4-trifluorocrotonate, 8.5 grams (0.032 mole) of ethyl N-(3-amino4-chloro-6-fluoro-2-methoxyphenyl)carbamate, and 2.2 grams (0.014 mole) of DBU in 75 mL of DMF. This preparation differs from well-known literature preparations for pyrimidinedione rings in that sodium trimethylsilanolate and DBU were used rather than sodium hydride. The yield of title compound was 1.7 grams. The NMR spectrum was consistent with the proposed structure.

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