Реакция #3624

Уравнение реакции

4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline

hydrazine

→

desired product

4,5-Dihydro-5(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline

Растворители

ethyl alcohol

Условия реакции

Обработка

1. 1
   Температураheating
2. 2
   Температураunder reflux for 2 hours
3. 3
   ФильтрацияThe hot reaction mixture is filtered through diatomaceous earth
4. 4
   Промывкаthe filter cake washed with hot chloroform
5. 5
   Концентрированиеthe filtrate concentrated in vacuo
6. 6
   ДругоеThe residue is triturated with ethyl acetate
7. 7
   Фильтрацияthe mixture filtered

Методика

To a solution of 1 mmol of 4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline in 20 ml of ethyl alcohol is added 0.2 g of 10% Pd/C and 2.5 mmol of hydrazine followed by stirring and heating under reflux for 2 hours. The hot reaction mixture is filtered through diatomaceous earth and the filter cake washed with hot chloroform and the filtrate concentrated in vacuo. The residue is triturated with ethyl acetate and the mixture filtered to give the desired product as crystals, m.p. 225°-228° C.

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