Реакция #362029

Уравнение реакции

2,3-dichloro-5-nitrophenylmethyl isocyanate

sodium hydride

ethyl 3-amino-4,4,4-trifluoro-2-butenoate

→

3-(2,3-dichloro-5-nitrophenylmethyl)-6-trifluoromethyluracil

Выход 55.8%

Растворители

N,N-dimethylformamide

Условия реакции

Методика

By the method of Example 1, Step G, 19.67 grams (0.080 mole) of 2,3-dichloro-5-nitrophenylmethyl isocyanate, 2.102 grams (0.088 mole) of sodium hydride, and 14.59 grams (0.080 mole) of ethyl 3-amino-4,4,4-trifluoro-2-butenoate were reacted in 80 mL of N,N-dimethylformamide, yielding 17.14 grams of 3-(2,3-dichloro-5-nitrophenylmethyl)-6-trifluoromethyluracil as a brown solid. The NMR spectrum was consistent with the proposed structure. This reaction was repeated.

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