Реакция #357935

Уравнение реакции

hydrochloric acid

sodium pyrophosphate

piperazine

→

piperazine pyrophosphate

Выход 46.0%

Растворители

water

water

Условия реакции

Обработка

1. 1
   Другоеlower, whereupon a white solid precipitated
2. 2
   ФильтрацияThe white solid was collected by filtration
3. 3
   Промывкаwashed with water
4. 4
   workup.ADDITIONTo the filtrate was added 300 g of methanol
5. 5
   Фильтрацияthe thus precipitated white solid was collected by filtration
6. 6
   Промывкаwashed with methanol and water
7. 7
   ДругоеThe combined white solid was dried

Методика

In 300 g of water was dispersed 0.5 mol of sodium pyrophosphate. The dispersion was cooled to 10° C., and 1 mol of hydrochloric acid was added thereto. To the dispersion was added 0.5 mol of piperazine (purity: 97%) dissolved in 800 g of water at 20° C. or lower, whereupon a white solid precipitated. The reaction system was stirred at 10° C. for 3 hours. The white solid was collected by filtration and washed with water. To the filtrate was added 300 g of methanol, and the thus precipitated white solid was collected by filtration and washed with methanol and water. The combined white solid was dried to give 0.23 mol of piperazine pyrophosphate as a white powder.

Источник