Реакция #357835

Уравнение реакции

2-thiopheneethanol

1,3,5-trioxane

→

title compound

Выход 121.2%

6,7-dihydro-4H-thieno[3,2-c]pyrane

Выход 121.2%

Растворители

butyronitrile

Условия реакции

Обработка

1. 1
   Температураthe resulting mixture was refluxed for 6 hours
2. 2
   Концентрированиеconcentrated by evaporation under reduced pressure
3. 3
   workup.DISTILLATIONThe residue was distilled under reduced pressure

Методика

10.0 g of 2-thiopheneethanol, 3.5 g of 1,3,5-trioxane, and 862 mg of indium(III) chloride were added to 1,500 mL of butyronitrile, and the resulting mixture was refluxed for 6 hours. The reaction product solution was cooled to room temperature and concentrated by evaporation under reduced pressure. The residue was distilled under reduced pressure to obtain 6.6 g (yield of 60%) of the title compound, of which analysis data were the same as obtained in Example 14.

Источник