Реакция #356836

Уравнение реакции

benzyl(2-aminoethyl)carbamate hydrochloride

HATU

N,N-diisopropylethylamine

N-(tert-butoxycarbonyl)-L-serine

DMF

→

Benzyl(2-{[N-(tert-butoxycarbonyl)-L-seryl]amino}ethyl)carbamate

Условия реакции

Обработка

1. 1
   workup.STIRRINGThe reaction mixture is stirred at RT for 15 h
2. 2
   ДругоеThe solvent is then evaporated
3. 3
   ПромывкаThe organic phase is washed with water
4. 4
   Сушкаdried over magnesium sulfate
5. 5
   Концентрированиеconcentrated
6. 6
   ДругоеThe crude product is purified by preparative HPLC

Методика

627.4 mg (1.650 mmol) of HATU and 387.7 mg (3.0 mmol) of N,N-diisopropylethylamine are added to a solution of 307.8 mg (1.50 mmol) of N-(tert-butoxycarbonyl)-L-serine in 25 ml of anhydrous DMF. After stirring at RT for 15 min, 380.6 mg (1.650 mmol) of benzyl(2-aminoethyl)carbamate hydrochloride are added. The reaction mixture is stirred at RT for 15 h. The solvent is then evaporated and the residue is taken up in dichloromethane. The organic phase is washed with water, dried over magnesium sulfate and concentrated. The crude product is purified by preparative HPLC.

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