Реакция #3559

Уравнение реакции

6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine

6-o-Tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

ammonia

→

title compound

1-(2-Amino-6-o-tolyl-pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl-urea

Растворители

methane

Условия реакции

Обработка

1. 1
   ДругоеThe product was purified by MPLC
2. 2
   Промывкаeluting with CHCl3 :EtOAc (1:1)
3. 3
   Другоеafford the pure product

Методика

The title compound was prepared from 6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 90 and tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with CHCl3 :EtOAc (1:1) afford the pure product; mp 195°-197° C., CIMS (1% ammonia in methane): m/z (relative intensity) 351 (MH+ +1, 55), 352 (MH+ +2, 12), 84 (100).

Источник