Реакция #355748

Уравнение реакции

2-fluoro-5-nitrotoluene

N-methylpyrrolidinone

4-amino-2-butanol

triethylamine

→

4-(4-nitro-2-methylphenylamino)butan-2-ol

Выход 82.3%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураafter cooling to room temperature
2. 2
   ДругоеThe yellow precipitate formed
3. 3
   Фильтрацияwas filtered off
4. 4
   Сушкаdried over P2O5

Методика

2 g of 2-fluoro-5-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.38 g of 4-amino-2-butanol and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 2.38 g of 4-(4-nitro-2-methylphenylamino)butan-2-ol (27) were obtained.

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