Реакция #355428

Уравнение реакции

compound

9-Anilino-7-methyl-1H-imidazo[4,5-f]quinoline Hydrochloride

3-chloro-2-methylaniline

dimethylformamide

→

9-(3-Chloro-2-methylanilino)-7-methyl-1H-imidazo[4,5-f]quinoline Hydrochloride Monohydrate

Условия реакции

Обработка

1. 1
   Другоеto yield a tar
2. 2
   Другоеto give a yellow semisolid
3. 3
   ДругоеThe yellow product was recrystallized twice from methanol/ether
4. 4
   Другоеto yield 14 g

Методика

A stirred reaction mixture of the compound of Example I, C. (22 g., 0.1 mole) and 3-chloro-2-methylaniline (14 g., 0.1 mole) in 200 ml. of dimethylformamide was refluxed for 6 hours. The reaction mixture was stripped in vacuo to yield a tar. Upon standing the tar solidified to give a yellow semisolid. The yellow product was recrystallized twice from methanol/ether to yield 14 g. (37%).

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