Реакция #354103

Уравнение реакции

2-methoxy-5-nitrobenzyl bromide

1,4,7,10-tetraazacyclododecane

→

N-(2-methoxy-5-nitrobenzyl)-1,4,7,10-tetraazacyclododecane

Выход 79.0%

Растворители

chloroform

chloroform

Условия реакции

Обработка

1. 1
   Фильтрацияwas filtered
2. 2
   Концентрированиеthe filtrate concentrated (in vacuo)
3. 3
   Другоеto give a residue which
4. 4
   Другоеwas chromatographed (silica, Solvent System 3)
5. 5
   ДругоеThe monoalkylated product was isolated in 79 percent yield (MP=154°-156° C.)

Методика

To a stirred chloroform solution (20 ml) containing 2.9 g of 1,4,7,10-tetraazacyclododecane (16.8 mmole) was added a chloroform solution (20 ml) containing 2.1 g of 2-methoxy-5-nitrobenzyl bromide (8.5 mmole) in one portion. After stirring at room temperature for three hours the reaction mixture was filtered and the filtrate concentrated (in vacuo) to give a residue which was chromatographed (silica, Solvent System 3). The monoalkylated product was isolated in 79 percent yield (MP=154°-156° C.), and characterized by:

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