Реакция #353370

ord-2f7de46d7cc9413b8ae78331c4bc43a7

Уравнение реакции

C(=NC1CCCCC1)=NC1CCCCC1
dicyclohexylcarbodiimide
C[C@@H]1C[C@@H]2O[C@@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1
radicicol
CC(=O)CCCCCCCCCCCCCCCC(O)=S
16-acetylthiohexadecanoic acid
→
CN(C)c1ccccn1
dimethylaminopyridine

Реактанты

C(=NC1CCCCC1)=NC1CCCCC1
dicyclohexylcarbodiimide
C[C@@H]1C[C@@H]2O[C@@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1
radicicol
CC(=O)CCCCCCCCCCCCCCCC(O)=S
16-acetylthiohexadecanoic acid

Реагенты

Нет

Растворители

C1CCOC1
tetrahydrofuran

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Following a procedure similar to that described in Example 12, but using 120 mg of radicicol, 206 mg of 16-acetylthiohexadecanoic acid, 5 ml of dry tetrahydrofuran, 330 mg of dicyclohexylcarbodiimide and a catalytic amount of dimethylaminopyridine, 235 mg of the title compound were obtained.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US05650430uspto-grants-1997_07