Реакция #353196

Уравнение реакции

benzyl bromide

2-(2-aminoethoxy) ethanol

potassium carbonate

water

→

1-Dibenzylamino-5-hydroxy-3-oxapentane

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Температураthe mixture is refluxed for 2 hours
2. 2
   Другоеevaporated under vacuum
3. 3
   Фильтрацияfiltered off from the salts
4. 4
   КонцентрированиеThe filtrate is concentrated under vacuum
5. 5
   Другоеpurified by flash chromatography (silica gel/mobile phase: methylene chloride/hexane/acetone:10/5/1)

Методика

A mixture of 50 g (475.56 mmol) of 2-(2-aminoethoxy) ethanol and 144.6 g (1.046 mol) of potassium carbonate in 600 ml of EtOH/60 ml of water is heated to 60° C. To this mixture is added dropwise within one hour 178.95 g (1.046 mol) of benzyl bromide and then the mixture is refluxed for 2 hours, evaporated under vacuum, the residue taken up with 1 liter of methylene chloride, and filtered off from the salts. The filtrate is concentrated under vacuum and purified by flash chromatography (silica gel/mobile phase: methylene chloride/hexane/acetone:10/5/1). Yield: 127.58 g (94% of theory) of a colorless oil.

Источник