Реакция #3510

Уравнение реакции

2-amino-7-chloro-6-(4-methoxyphenyl)-pyrido[2,3-d]pyrimidine

2-Amino-7-chloro-6-(4-methoxyphenyl)-pyrido[2,3-d]-pyrimidine

methylamine

→

title compound

6-(4-Methoxyphenyl)-N7 -methyl-pyrido[2,3-d]pyrimidine-2,7-diamine

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураwere heated in a bomb on a steam bath for 4 hours
2. 2
   ТемператураAfter cooling
3. 3
   Промывкаthe suspension was washed out of the bomb with 50 mL of methanol/water (50:50)
4. 4
   Другоеthe solvents were evaporated in vacuo
5. 5
   Фильтрацияfiltered
6. 6
   Другоеcrystallized from ethanol

Методика

A mixture of 3.4 g of 2-amino-7-chloro-6-(4-methoxyphenyl)-pyrido[2,3-d]pyrimidine from Example 12, 40 mL of anhydrous methylamine, and 10 mL of methanol were heated in a bomb on a steam bath for 4 hours. After cooling, the suspension was washed out of the bomb with 50 mL of methanol/water (50:50) and the solvents were evaporated in vacuo. The solid residue was slurried with 50 mL of water, filtered, and crystallized from ethanol to afford 2.2 g of the title compound 6-(4-methoxyphenyl)-N7 -methyl-pyrido[2,3-d]pyrimidine-2,7-diamine, mp 270°-275° C. dec.

Источник