Реакция #3502

Уравнение реакции

water

potassium carbonate

chloromethylpropargyl ether

N-methoxybenzamide

→

N-methoxy-N-propargyloxymethylbenzamide

Выход 91.9%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   Экстракцияthe mixture was extracted with ethyl acetate
3. 3
   ДругоеThe extract was dried
4. 4
   Концентрированиеconcentrated
5. 5
   Другоеpurified by silica gel column chromatography

Методика

0.6 g of N-methoxybenzamide was dissolved in 10 ml of acetonitrile, and 0.55 g of potassium carbonate and 0.42 g of chloromethylpropargyl ether were added thereto in this order. The mixture was stirred at room temperature for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.8 g of N-methoxy-N-propargyloxymethylbenzamide.

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