Реакция #3501

Уравнение реакции

N-methoxy-2,4-dichlorobenzamide

potassium carbonate

propargyl bromide

N,N-dimethylformamide

→

propargyl N-methoxy-2,4-dichlorobenzimidate

Выход 29.8%

Растворители

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   Экстракцияthe mixture was extracted with ethyl acetate
3. 3
   ДругоеThe extract was dried
4. 4
   Концентрированиеconcentrated
5. 5
   Другоеpurified by silica gel column chromatography

Методика

1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.

Источник