Реакция #349478

Уравнение реакции

2-bromopropionylchloride

3-phenylindoline

triethylamine

→

N-(2-bromopropionyl)-3-phenylindoline

Выход 96.6%

Растворители

benzene

benzene

Условия реакции

Обработка

1. 1
   ПромывкаThe mixture was then washed with water
2. 2
   Сушкаthe benzene layer dried over sodium sulfate
3. 3
   Другоеthe solvent removed in vacuo at room temperature

Методика

A solution of 3.0 g of 2-bromopropionylchloride in 5 ml of benzene was added dropwise at 10° C. to a mixture of 3.0 g of 3-phenylindoline, 3.0 ml of triethylamine in 30 ml of dry benzene. The mixture was then washed with water, the benzene layer dried over sodium sulfate and the solvent removed in vacuo at room temperature to leave 4.9 g of the desired N-(2-bromopropionyl)-3-phenylindoline as a resin.

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