Реакция #3491

Уравнение реакции

KOH

6-chloropurine

HCl

3,5-diacetylaniline

→

6-[(3,5-diacetylphenyl)amino]purine

Выход 90.4%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураat reflux for 30 min
3. 3
   ТемператураAfter cooling the mixture
4. 4
   Фильтрацияthe solid was filtered out
5. 5
   Промывкаwashed with water
6. 6
   Другоеdried

Методика

Compound No. 16: A suspension of 3,5-diacetylaniline (0.531 g) in water (10 mL) was treated with 6-chloropurine (0.464 g) and concentrated HCl (0.25 mL) and heated at reflux for 30 min. After cooling the mixture was treated with 6 mL of aqueous 1N KOH. The mixture was stirred for 10 min and the solid was filtered out, washed with water, and dried, to give 0.80 g of 6-[(3,5-diacetylphenyl)amino]purine, mp dec 340°-350° C.

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