Реакция #348433

ord-65c78d0aa7cc49bfa6cfeb9ca324a557

Уравнение реакции

COC(=O)C1N2C(=O)C(NC(=O)COc3ccccc3)[C@H]2SC1(C)CBr
methyl 2-bromomethyl-2-methyl-6-(2-phenoxyacetamido)penam-3-carboxylate
Nc1ccccc1
aniline
COC(=O)C1N2C(=O)C(NC(=O)COc3ccccc3)[C@H]2SC1(C)CNc1ccccc1
methyl 2-anilinomethyl-2-methyl-6-(2-phenoxyacetamido)-penam-3-carboxylate
Выход 45.3%

Растворители

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    workup.ADDITIONBy treating in the similar manner

Методика

By treating in the similar manner as described in Example 16 using methyl 2-bromomethyl-2-methyl-6-(2-phenoxyacetamido)penam-3-carboxylate (0.88 g), aniline (0.28 g), silver fluoroborate (0.43 g) and methylene chloride (15 ml), there was obtained oily methyl 2-anilinomethyl-2-methyl-6-(2-phenoxyacetamido)-penam-3-carboxylate (0.41 g) from the fractions of the third to seventh.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US04164497uspto-grants-1979_08