Реакция #346449

Уравнение реакции

2,3-Epoxypropyl isopropyl ether

sodium hydride

n-dodecylthiol

→

1-(n-dodecylthio)-3-isopropoxy-2-propanol

Растворители

tetrahydrofuran

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Другоеformed by the addition of 50 mg
2. 2
   ДругоеAfter approximately 4 hours the solvent is removed from the reaction mixture and 20 ml
3. 3
   workup.ADDITIONof water is added to the residue
4. 4
   ЭкстракцияThe resultant aqueous mixture is extracted with ether
5. 5
   Промывкаthe ether extracts washed with water
6. 6
   Сушкаdried over magnesium sulfate
7. 7
   Другоеevaporated

Методика

2,3-Epoxypropyl isopropyl ether (1.16 g.) in several ml. of dry tetrahydrofuran is added to a stirred suspension formed by the addition of 50 mg. of sodium hydride (56% dispersion in mineral oil) to 2.2 g. 8. of n-dodecylthiol in 50 ml. tetrahydrofuran. The mixture is then stirred at 60° C. After approximately 4 hours the solvent is removed from the reaction mixture and 20 ml. of water is added to the residue. The resultant aqueous mixture is extracted with ether and the ether extracts washed with water, dried over magnesium sulfate and evaporated to yield 1-(n-dodecylthio)-3-isopropoxy-2-propanol.

Источник