Реакция #346356

Уравнение реакции

hydrochloric acid

Acetic acid

6-(2-phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid

sodium percarbonate

→

6-(2-phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid-1-oxide

Растворители

water

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Другоеat 10° - 15° C
3. 3
   ФильтрацияThe precipitate was collected by filtration
4. 4
   Промывкаwashed with water
5. 5
   Другоеdried

Методика

Acetic acid (10 cc) was added to 6-(2-phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid (1.75 g.), and sodium percarbonate (1.89 g.) was added thereto at 10° - 15° C. To the mixture were added water (2 cc) and sodium tungstate dihydrate (120 mg.), and the mixture was stirred for 2 hours. The mixture was acidified to a pH 3 with water (50 cc) and 10% hydrochloric acid. The precipitate was collected by filtration, washed with water and dried to yield crude crystals (1.31 g.) of 6-(2-phenoxyacetamido)-2,2-dimethylpenam-3-carboxylic acid-1-oxide, m.p. 160° - 161° C.

Источник