Реакция #344333

Уравнение реакции

2-(2-allyloxy-5-tert-butylphenyl)-2-phenylacetic acid

compound ( 105 )

2-(2-allyloxy-5-tert-butylphenyl)-2-phenylacetic acid

stearyl alcohol

dichloromethane

N,N'-dicyclohexylcarbodiimide

→

stearyl 2-(2-allyloxy-5-tert-butylphenyl)-2-phenylacetate

Выход 69.3%

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction mixture is filtered
2. 2
   Концентрированиеconcentrated on a vacuum rotary evaporator

Методика

A solution of 3.24 g (10.0 mmol) of 2-(2-allyloxy-5-tert-butylphenyl)-2-phenylacetic acid (compound (105), Example 2) and 2.70 g (10.0 mmol) of stearyl alcohol (1-octadecanol) in 25 mol of dichloromethane is treated with 100 mg (0.82 mmol) of 4-dimethylaminopyridine and 2.20 g (10.7 mmol) of N,N'-dicyclohexylcarbodiimide, and the mixture is stirred for 60 hours at room temperature. The reaction mixture is filtered and concentrated on a vacuum rotary evaporator. Chromatography of the residue from silica gel using the diluent system dichloromethane/hexane=1:1 yields 4.0 g (69%) of stearyl 2-(2-allyloxy-5-tert-butylphenyl)-2-phenylacetate (compound (106), Table 1) as an oil.

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