Реакция #343285

Уравнение реакции

methyl 3-(3-cyclohexyl-4-hydroxy-5-methylphenyl)propionate

octadecanol

lithium amide

→

octadecyl 3-(3-cyclohexyl-4-hydroxy-5-methylphenyl)propionate

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThe methanol forming is continuously distilled off
2. 2
   Другоеcan be purified by column chromatography

Методика

27.6 g of methyl 3-(3-cyclohexyl-4-hydroxy-5-methylphenyl)propionate and 27.1 g of octadecanol are heated, under nitrogen, to 80° C. as described in Example 2. After the addition of 0.1 g of lithium amide, the reaction mixture is heated for 10 hours at 150° C. The methanol forming is continuously distilled off. The yield is 30.2 g of crude product which is in the form of a yellowish oil and can be purified by column chromatography.

Источник