Реакция #342580

Уравнение реакции

ethyl acetoacetate

trifluoroaceto-nitrile

→

enamine

Выход 62.0%

Ethyl 2-acetyl-3-amino-4,4,4-trifluoro-2-butenoate

Выход 62.0%

Условия реакции

Обработка

1. 1
   ДругоеTo a 1 liter, four-necked flask equipped with nitrogen inlet
2. 2
   workup.ADDITIONwas added
3. 3
   ПромывкаThe reaction mixture was washed with hexane
4. 4
   Другоеthe resulting solid was dried in vacuo

Методика

To a 1 liter, four-necked flask equipped with nitrogen inlet, thermometer, and mechanical stirrer was charged 499.74 g (490 ml, 3.84 mol) of ethyl acetoacetate and 12.9 g (0.115 mol) of potassium-t-butoxide. The resulting mixture was stirred while 391 g (4.04 mol) of trifluoroaceto-nitrile was added. The reaction mixture was washed with hexane and the resulting solid was dried in vacuo affording 535 g (62%) of the enamine as a yellow solid; mp 63°-65° C.

Источник