Реакция #341808

Уравнение реакции

triethylamine

product

1-((5-tert-butyl-2-iminothiazol-3(2H)-yl)methyl)cyclohexanol

5-chloro-2-methoxybenzoic acid

thionyl chloride

→

title compound

Выход 51.4%

(Z)-N-(5-tert-butyl-3-((1-hydroxycyclohexyl)methyl)thiazol-2(3H)-ylidene)-5-chloro-2-methoxybenzamide

Выход 51.4%

Растворители

THF

Условия реакции

Методика

The product of Example 20A (1.3 g, 3.7 mmol), 5-chloro-2-methoxybenzoic acid (0.70 g, 3.7 mmol), thionyl chloride (10 mL) and triethylamine (1.6 mL, 11 mmol) in THF (25 mL) were processed as described in Example 18B and Example 18C to provide the title compound (0.82 g, 1.9 mmol, 50% yield). MS (DCI/NH3) m/z 437 (M+H)+.

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