Реакция #339117

Уравнение реакции

chloral hydrate

3-chloro-2-methylaniline

sodium sulfate

hydrochloric acid

hydroxylamine hydrochloride

→

N-(3-chloro-2-methylphenyl)-2-(hydroxyimino)acetamide

Выход 47.6%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураthe mixture was heated
2. 2
   Температураto reflux for 30 minutes
3. 3
   Температураcooled
4. 4
   Фильтрацияa deposited precipitate was collected by filtration

Методика

A mixture of 4.62 g of chloral hydrate, 3.5 g of 3-chloro-2-methylaniline, 30 g of anhydrous sodium sulfate, 120 ml of water and 2 ml of 2N hydrochloric acid was stirred at room temperature for 2 hours. Then, to the resulting mixture, 1.8 g of hydroxylamine hydrochloride was added, and the mixture was heated to reflux for 30 minutes. The reaction mixture was ice-cooled, and a deposited precipitate was collected by filtration to obtain 2.5 g of N-(3-chloro-2-methylphenyl)-2-(hydroxyimino)acetamide of the formula:

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