Реакция #3366

Уравнение реакции

4-aminophenylacetic acid

triethylamine

2-chlorosulfenylbenzoyl chloride

→

title compound

Выход 69.4%

4-(3-Oxo-3h-benzo [d]isothiazol-2-yl) phenylacetic acid

Выход 69.4%

Растворители

ethyl cellosolve

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated in vacuo, and water
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   Фильтрацияfiltered

Методика

To a mixture of 7.55 g (0.05 mol) of 4-aminophenylacetic acid and 15.15 g (0.15 mol) of triethylamine in 25 mL of ethyl cellosolve was added 10.3 g (0.05 mol) of 2-chlorosulfenylbenzoyl chloride (Arzneimittel Forsch., 1964;14:1301). The mixture was stirred at room temperature for 3 hours, concentrated in vacuo, and water was added to the residue. The mixture was acidified with HCl and filtered to give 9.9 g of the title compound, mp 173°-175° C.

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