Реакция #3361

Уравнение реакции

2-[2-(1-carboxy-2-methylbutylcarbamoyl) phenyldisulfanylbenzoylamino]-3-methylpentanoic acid

bromine

→

title compound

3-Methyl-2-(3-oxo-3h-benzo[d]isothiazol-2-yl)pentanoic acid

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated to dryness in vacuo
2. 2
   ДругоеThe residue was triturated with dichloromethane
3. 3
   ДругоеThe dichloromethane was removed by evaporation in vacuo
4. 4
   Другоеto remove excess bromine
5. 5
   ДругоеThe residue was partitioned between dichloromethane/5% aqueous sodium bicarbonate (200 mL each)
6. 6
   ДругоеThe aqueous layer was separated
7. 7
   Промывкаwashed with fresh dichloromethane
8. 8
   ЭкстракцияThe acidic aqueous solution was extracted with dichloromethane (2×75 mL)
9. 9
   Промывкаwashed with water
10. 10
    Сушкаdried (MgSO4)
11. 11
    Фильтрацияfiltered
12. 12
    Концентрированиеconcentrated to dryness in vacuo

Методика

To a stirred suspension of 5.3 g (10.0 mmol) of [S-(R*,R*)]-2-[2-[2-(1-carboxy-2-methylbutylcarbamoyl) phenyldisulfanylbenzoylamino]-3-methylpentanoic acid (from Preparation 19) in 200 mL of dichloromethane was added dropwise 2.4 g (15.0 mmol) of liquid bromine. The reaction mixture was stirred at room temperature for 2 hours and concentrated to dryness in vacuo. The residue was triturated with dichloromethane. The dichloromethane was removed by evaporation in vacuo to remove excess bromine. The residue was partitioned between dichloromethane/5% aqueous sodium bicarbonate (200 mL each). The aqueous layer was separated, washed with fresh dichloromethane, and acidified to pH 1.5 with 6.0M hydrochloric acid. The acidic aqueous solution was extracted with dichloromethane (2×75 mL). The organic layers were combined, washed with water, dried (MgSO4), filtered and concentrated to dryness in vacuo to give 4.8 g of the title compound, mp 50°-52° C.

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