Реакция #335656

Уравнение реакции

2-(3-methylbenzo[b]thien-2-yl)piperazine

7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

→

desired product

1-Ethyl-6-fluoro-1,4-dihydro-7-[3-(3-methylbenzo[b]-thien-2-yl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid

Растворители

pyridine

Условия реакции

Обработка

1. 1
   Температураthe mixture was heated in a pressure bottle, under argon at 120°-130° C. for 18 hours
2. 2
   ДругоеThe solid was collected
3. 3
   Промывкаwashed with pyridine
4. 4
   Другоеether and recrystallized from dimethylformamide

Методика

A 2 g portion of 2-(3-methylbenzo[b]thien-2-yl)piperazine was added to 7 ml of pyridine. A 780 mg portion of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid was added and the mixture was heated in a pressure bottle, under argon at 120°-130° C. for 18 hours. The solid was collected, washed with pyridine, then ether and recrystallized from dimethylformamide, giving 540 mg of the desired product, mp 302°-304° C. (dec.).

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