Реакция #334986

Уравнение реакции

hydrochloric acid

2-fluoro-4-hydroxybenzoic acid

tridecanoyl chloride

dimethylaminopyridine

→

titled compound

Выход 59.4%

2-fluoro-4-n-tridecanoyloxybenzoic acid

Выход 59.4%

Растворители

dichloromethane

triethylamine

Условия реакции

Обработка

1. 1
   ДругоеThe organic layer was separated by a funnel
2. 2
   workup.DISTILLATIONdistilled
3. 3
   Другоеto remove the solvent
4. 4
   ПромывкаThe residue was washed with n-hexane
5. 5
   Другоеdried

Методика

To a solution of 2-fluoro-4-hydroxybenzoic acid (1.4 g) and triethylamine (1.0 g) in dichloromethane (40 ml) were added tridecanoyl chloride (2.0 g) and dimethylaminopyridine (0.2 g). The solution was stirred at room temperature for about 20 hours and thereto was added dilute aqueous hydrochloric acid solution. The organic layer was separated by a funnel and distilled to remove the solvent. The residue was washed with n-hexane and dried to obtain the titled compound (about 1.8 g).

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