Реакция #334985

Уравнение реакции

hydrochloric acid

2-fluoro-4-hydroxybenzoic acid

decanoylchloride

dimethylaminopyridine

→

titled compound

Выход 70.4%

2-fluoro-4-n-decanoyloxybenzoic acid

Выход 70.4%

Растворители

dichloromethane

triethylamine

Условия реакции

Обработка

1. 1
   Другоеthe organic layer was separated by a funnel
2. 2
   workup.DISTILLATIONThe layer was distilled
3. 3
   Другоеto remove the solvent
4. 4
   ПромывкаThe residue was washed with n-hexane
5. 5
   Другоеdried

Методика

To a solution of 2-fluoro-4-hydroxybenzoic acid (2 g) and triethylamine (1.4 g) in dichloromethane (40 ml) were added decanoylchloride (2.7 g) and dimethylaminopyridine (0.2 g). The solution was stirred at room temperature for about 20 hours. To the solution was added dilute aqueous hydrochloric acid solution and the organic layer was separated by a funnel. The layer was distilled to remove the solvent. The residue was washed with n-hexane and dried to obtain the titled compound (about 2.8 g).

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