Реакция #3341

Уравнение реакции

2-dimethylaminobenzylchloride hydrochloride

5,5-dimethyl-2,4-dithiohydantoin

→

2-(2-dimethylaminobenzylthio)-5,5-dimethylimidazolin-4-thione

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Промывкаwashed with an aqueous solution of NaHCO3
2. 2
   Сушкаdried over MgSO4
3. 3
   Концентрированиеconcentrated in vacuo
4. 4
   workup.ADDITIONThe residue was treated

Методика

Initially, 11 g of 2-dimethylaminobenzylchloride hydrochloride was added to a solution of 8 g of 5,5-dimethyl-2,4-dithiohydantoin in 200 mL of chloroform (CHCl3) at about 60° C. The reaction mixture was stirred for 30 minutes and washed with an aqueous solution of NaHCO3, dried over MgSO4, and concentrated in vacuo. The residue was treated following the procedure used for the compound (a). As a result, the desired compound of 2-(2-dimethylaminobenzylthio)-5,5-dimethylimidazolin-4-thione was isolated by column chromatography. The yield of this compound was 9.1 g with a yield ratio of 62.1%. Further, the desired compound of 2,4-bis(2-dimethylaminobenzylthio)-5,5-dimethyl-5H-imidazole was isolated. The yield of this compound was 1.2 g with a yield ratio of 5.6%.

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