Реакция #331706

Уравнение реакции

Methanesulphonyl chloride

N,N-dimethyl-1,3-phenylenediamine

sodium hydroxide

→

material

Выход 79.0%

N-[3-(dimethylamino)phenyl]methanesulphonamide

Выход 79.0%

Растворители

water

Условия реакции

Обработка

1. 1
   ЭкстракцияThe mixture was extracted with chloroform (3×15 cm3)
2. 2
   СушкаThe combined extracts were dried over sodium sulphate
3. 3
   Фильтрацияfiltered
4. 4
   Другоеthe solvent removed under reduced pressure

Методика

Methanesulphonyl chloride (838 mg, 7.35 mmol) was added slowly to a cooled solution (5° C.) of N,N-dimethyl-1,3-phenylenediamine (1.00 g, 7.35 mmol) and sodium hydroxide (5M, 1.5 cm3) in water (10 cm3). The reaction was allowed to warm to room temperature overnight. The mixture was extracted with chloroform (3×15 cm3). The combined extracts were dried over sodium sulphate, filtered and the solvent removed under reduced pressure. Column chromatography (1:20 methanol/dichloromethane) gave the target material as a brown oil (1.24 g, 79%).

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