Реакция #3272

Уравнение реакции

2-amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7(8H)-one

2-amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-ol

NaH

1-Iodopropane

→

2-amino-6-(2,6-dichlorophenyl)-8-propyl-8H-pyrido[2,3-d]pyrimidin-7-one

Выход 68.0%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Другоеresulting in a clear solution
2. 2
   Температураcooled to room temperature
3. 3
   ДругоеThe resulting precipitate was removed by filtration
4. 4
   Промывкаwashed with water
5. 5
   ДругоеThe residue was dried
6. 6
   Другоеpurified by flash chromatography
7. 7
   Промывкаeluting with 1:1 hexane

Методика

To a suspension of NaH (60% in mineral oil, 31 mg) in 6 mL of dimethylformamide was added 2-amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7(8H)-one from Example 11 (205 mg, 0.67 mmol). The mixture was heated at 50° C. for 1 hour resulting in a clear solution. 1-Iodopropane (100 μL, 1.03 mmol) was added, and the solution was stirred at 50° C. for 10 minutes, then cooled to room temperature and poured onto 40 mL of ice water. The resulting precipitate was removed by filtration and washed with water. The residue was dried and purified by flash chromatography, eluting with 1:1 hexane:ethyl acetate to provide 159 mg (68%) of 2-amino-6-(2,6-dichlorophenyl)-8-propyl-8H-pyrido[2,3-d]pyrimidin-7-one; mp 196°-197° C.

Источник