Реакция #325211

Уравнение реакции

4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine

naphthalen-2-yl-2-boronic acid

Na2CO3

→

ZK102

Выход 26.2%

4-chloro-7-methyl-5-(naphthalen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

Выход 26.2%

Растворители

THF

Условия реакции

Обработка

1. 1
   Температураto reflux overnight under an argon atmosphere
2. 2
   ДругоеReaction
3. 3
   Концентрированиеwas concentrated in vacuo
4. 4
   Другоеpurified by RP-HPLC (MeCN:H2O:0.1% TFA)

Методика

A solution of 4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (19 mg, 0.065 mmol), naphthalen-2-yl-2-boronic acid (12.2 mg, 0.071 mmol), Na2CO3 (68.9 mg, 0.65 mmol) and PdCl2(dppf) (26.5 mg, 0.00325 mmol) in THF (3 mL) was heated to reflux overnight under an argon atmosphere. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA) to yield ZK102 (5 mg, 26% yield). ESI-MS (M+H)+ m/z calcd 294.1, found 294.3.

Источник