Реакция #324681

Уравнение реакции

3-Bromo-2-methylphenol

3-(methylthio)propanol

tri-n-butyl phosphine

1,1′-(azodicarbonyl)dipiperidine

→

product

(3-(3-Bromo-2-methylphenoxy)propyl)(methyl)sulfane

Растворители

Water

tetrahydrofurane

Условия реакции

Обработка

1. 1
   Экстракцияthe mixture extracted with diethyl ether
2. 2
   ПромывкаThe organic layer is washed with brine
3. 3
   Сушкаdried (Na2SO4)
4. 4
   Другоеvolatiles removed under reduced pressure

Методика

3-Bromo-2-methylphenol (0.10 g), 3-(methylthio)propanol (0.055 mL), tri-n-butyl phosphine (0.12 g) and 1,1′-(azodicarbonyl)dipiperidine (0.15 g) are stirred in tetrahydrofurane for 16 hours. Water is added and the mixture extracted with diethyl ether. The organic layer is washed with brine, dried (Na2SO4) and volatiles removed under reduced pressure. The product (80 mg) is obtained after column chromatography (silica gel, n-hexane/ethyl acetate gradient 100:0 to 50:50).

Источник