Реакция #324411

Уравнение реакции

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetic acid

oxalyl dichloride

→

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   Температураthe mixture was heated
2. 2
   Другоеwhile elevating to room temperature
3. 3
   КонцентрированиеThe mixture was concentrated under reduced pressure

Методика

Under an argon atmosphere, to a solution of 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetic acid (9) (1.40 g, 5.26 mmol) in CH2Cl2 (10 mL) was added DMF (3 drops) by a Pasteur pipette at room temperature. To this was added oxalyl dichloride (890 μL, 10.5 mmol) at 0° C. and the mixture was heated with stirring for 30 minutes while elevating to room temperature. The mixture was concentrated under reduced pressure to give crude 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride (10) as a colorless oil, which was used in the following reaction without further purification.

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