Реакция #324400

Уравнение реакции

5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(thieno[3,2-b:2′,3′-d]thiophen-2-yl)pyrazin-2-amine

5-[4-(tert-Butyldimethylsilyloxy)phenyl]-3-(dithieno[3,2-b:2′,3′-d]thiophen-2-yl)pyrazin-2-amine

2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

water

→

Compound 11l

Выход 20.9%

2-[4-(tert-Butyldimethylsilyloxy)phenyl]-N-[5-{4-(tert-butyldimethylsilyloxy)phenyl}-3-(dithieno[3,2-b:2′,3′-d]thiophen-2-yl)pyrazin-2-yl]acetamide

Выход 20.9%

Растворители

pyridine

Условия реакции

Обработка

1. 1
   Другоеprepared above at 0° C.
2. 2
   Температураthe mixture was heated
3. 3
   ТемператураAfter cooling to room temperature
4. 4
   Экстракцияthe product was extracted with ethyl acetate (100 mL×3)
5. 5
   ЭкстракцияThe combined organic extract
6. 6
   Промывкаwas washed successively with water (200 mL) and brine (200 mL)
7. 7
   Сушкаby drying over anhydrous sodium sulfate
8. 8
   ФильтрацияAfter filtration and concentration under reduced pressure
9. 9
   Другоеthe residue was purified by column chromatography (silica gel 50 g, n-hexane/ethyl acetate=3/1)
10. 10
    ДругоеThe resulting solid was recrystallized (n-hexane/ethyl acetate)

Методика

Under an argon atmosphere, to a mixture of 5-[4-(tert-butyldimethylsilyloxy)phenyl]-3-(thieno[3,2-b:2′,3′-d]thiophen-2-yl)pyrazin-2-amine (7l) (370 mg, 746 μmol) and 4-(dimethylamino)pyridine (14.8 mg, 121 μmol) dissolved in anhydrous pyridine (15 mL) was added 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride (10) prepared above at 0° C. and the mixture was heated with stirring at 50° C. for 20 hours. After cooling to room temperature, to this was added water and the product was extracted with ethyl acetate (100 mL×3). The combined organic extract was washed successively with water (200 mL) and brine (200 mL), followed by drying over anhydrous sodium sulfate. After filtration and concentration under reduced pressure, the residue was purified by column chromatography (silica gel 50 g, n-hexane/ethyl acetate=3/1). The resulting solid was recrystallized (n-hexane/ethyl acetate) to give Compound 11l (116 mg, 156 μmol, 20.9%) as a brown solid. Rf=0.19 (n-hexane/ethyl acetate=3/1); 1H NMR (400 MHz, DMSO-d6) δ 0.16 (s, 6H), 0.21 (s, 6H), 0.93 (s, 9H), 0.94 (s, 9H), 3.68 (s, 2H), 6.78-6.88 (AA′BB′, 2H), 6.94-7.06 (AA′BB′, 2H), 7.20-7.30 (AA′BB′, 2H), 7.47 (d, 1H, J=5.2 Hz), 7.65 (s, 1H), 7.75 (d, 1H, J=5.2 Hz), 8.06-8.14 (AA′BB′, 2H), 8.93 (s, 1H), 10.72 (s, 1H); IR (KBr, cm−1) 530, 602, 644, 700, 779, 837, 922, 1072, 1171, 1265, 1361, 1447, 1504, 1603, 1657, 2857, 2928, 2955, 3208.

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