Реакция #324361

Уравнение реакции

Tolterodine tartrate

→

Tolterodin

Растворители

water

Условия реакции

Обработка

1. 1
   ДругоеDry pellet cores
2. 2
   workup.DISSOLUTIONWithin first hour almost 50% dissolves, however between 7 and 16 hours
3. 3
   workup.DISSOLUTIONless dissolves

Методика

Tolterodine tartrate, microcrystalline cellulose and part of ethylcellulose are blended with small amount of water into homogeneous blend from which pellet cores are made by extrusion and spheronization. Dry pellet cores are coated with the coating dispersion of Example 8. Within first hour almost 50% dissolves, however between 7 and 16 hours less dissolves as compared to Example 2.

Источник