Реакция #324356

Уравнение реакции

aniline

N,N-diisopropylethylamine

propane sultone

→

di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate

Выход 94.0%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated
2. 2
   workup.ADDITIONethylacetate was added
3. 3
   ФильтрацияThe precipitated DIPEA bromide was filtered off
4. 4
   Другоеthe filtrate was evaporated
5. 5
   workup.ADDITIONThe residue was treated with ether

Методика

A mixture of aniline (7 mmol), N,N-diisopropylethylamine (DIPEA, 18 mmol) and propane sultone (16 mmol) was heated in a pressure tube in 10 mL of acetonitrile at 120-130° C. for 9 h under argon atmosphere. The solvent was evaporated and ethylacetate was added. The precipitated DIPEA bromide was filtered off and the filtrate was evaporated. The residue was treated with ether to give di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate as a white or pinky-white solid. Yield: 94%.

Источник