Реакция #323897

Уравнение реакции

dimethyl cyanodithioimidocarbonate

1,1-dimethylpropargylamine

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title product

N-Cyano-N'-(2-methyl-3-butyn-2-yl)-S-methyl Isothiourea

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураat reflux temperature for 13 days
2. 2
   ДругоеThe reaction mixture was evaporated under reduced pressure
3. 3
   Другоеthe residue chromatographed on silica gel
4. 4
   Другоеthe product was recrystallized from toluene

Методика

A solution of dimethyl cyanodithioimidocarbonate (9.0 g, 0.615 mole) and 1,1-dimethylpropargylamine (90% amine, remainder water, 5.68 g, 0.0615 mole) in acetonitrile (125 ml) was stirred at reflux temperature for 13 days. The reaction mixture was evaporated under reduced pressure and the residue chromatographed on silica gel. The appropriate fractions were combined and the product was recrystallized from toluene to give the title product, mp 128°-130.5° C.

Источник