Реакция #323012

Уравнение реакции

2-amino-7-chloro-1,8-naphthyridine

3-fluorophenol

potassium hydroxide

→

2-Amino-7-(3-fluorophenoxy)-1,8-naphthyridine

Выход 64.5%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ПромывкаAfter treatment with caustic soda and washing
2. 2
   Другоеthe product produced (23.5 g; m.p. 161° C.)
3. 3
   workup.DISSOLUTIONis dissolved
4. 4
   Другоеthe crystallised solid is separated by filtration
5. 5
   Промывкаwashed with acetonitrile (2×10 cc)
6. 6
   Другоеdried at 40° C. under reduced pressure (0.067 kPa)

Методика

The procedure is similar to that described in Example 37, but starting with 2-amino-7-chloro-1,8-naphthyridine (18 g), 3-fluorophenol (44.8 g) and potassium hydroxide pellets (13.2 g; 85% purity). After treatment with caustic soda and washing, the product produced (23.5 g; m.p. 161° C.) is dissolved in boiling acetonitrile (120 cc). After 2 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (2×10 cc) and dried at 40° C. under reduced pressure (0.067 kPa). 2-Amino-7-(3-fluorophenoxy)-1,8-naphthyridine (16.5 g) is produced, m.p. 165° C.

Источник