Реакция #323009

Уравнение реакции

ethanol

4-methoxybenzoic acid

2-amino-7-(2-fluorophenoxy)-1,8-naphthyridine

→

N-[7-(2-fluorophenoxy)-1,8-naphthyridin-2-yl]-4-methoxybenzamide

Выход 32.6%

Растворители

water

Условия реакции

Обработка

1. 1
   workup.DISSOLUTIONis dissolved
2. 2
   Другоеthe crystallised solid is separated by filtration
3. 3
   Промывкаwashed with ethanol (2×10 cc)
4. 4
   Другоеdried at 40° C. under reduced pressure (0.067 kPa)

Методика

The procedure is similar to that described in Example 1, but starting with 4-methoxybenzoic acid (6.1 g), N,N'-carbonyldiimidazole (6.5 g) and 2-amino-7-(2-fluorophenoxy)-1,8-naphthyridine (7.65 g). The product produced by precipitation in water (5.5 g; m.p. 200° C.) is dissolved in boiling ethanol (180 cc). After 2 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with ethanol (2×10 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-[7-(2-fluorophenoxy)-1,8-naphthyridin-2-yl]-4-methoxybenzamide (3.8 g) is produced, m.p. 208° C.

Источник