Реакция #323003

Уравнение реакции

3-methoxybenzoic acid

2-amino-7-methoxy-1,8-naphthyridine

→

N-(7-methoxy-1,8-naphthyridin-2-yl)-3-methoxybenzamide

Выход 70.4%

Растворители

water

acetonitrile

Условия реакции

Обработка

1. 1
   Другоеthe crystallised solid is separated by filtration
2. 2
   Промывкаwashed with acetonitrile (3×10 cc)
3. 3
   Другоеdried at 50° C. under reduced pressure (0.067 kPa)

Методика

The procedure is similar to that described in Example 1, but starting with 3-methoxybenzoic acid (9.1 g), N,N'-carbonyldiimidazole (9.7 g) and 2-amino-7-methoxy-1,8-naphthyridine (7 g). The product produced by precipitation in water (13 g; m.p. approximately 75° C.) is dissolved in 90 cc of boiling acetonitrile. After 3 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (3×10 cc) and dried at 50° C. under reduced pressure (0.067 kPa). N-(7-methoxy-1,8-naphthyridin-2-yl)-3-methoxybenzamide (8.7 g) is produced, m.p. 135° C.).

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