Реакция #322992

Уравнение реакции

2-amino-7-chloro-1,8-napthyridine

4-methoxyphenol

potassium hydroxide

→

2-amino-7-(4-methoxyphenoxy)-1,8-naphthyridine

Выход 99.3%

Условия реакции

Обработка

1. 1
   ПромывкаAfter treatment with caustic soda and washing

Методика

The procedure is similar to that described in Example 4, but starting with 2-amino-7-chloro-1,8-napthyridine (35.8 g), 4-methoxyphenol (99.2 g) and potassium hydroxide pellets (22.4 g; 85% purity). After treatment with caustic soda and washing, 2-amino-7-(4-methoxyphenoxy)-1,8-naphthyridine (52.9 g) is produced, m.p. 200° C. EXAMPLE 13

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