Реакция #322991

Уравнение реакции

acetonitrile

benzoic acid

2-amino-7-(4-methoxyphenoxy)-1,8-naphthyridine

→

N-[7-(4-methoxyphenoxy)-1,8-naphthyridin-2-yl]benzamide

Выход 73.8%

Растворители

water

Условия реакции

Обработка

1. 1
   workup.DISSOLUTIONis dissolved
2. 2
   Другоеthe crystallised solid is separated by filtration
3. 3
   Промывкаwashed with acetonitrile (2×5 cc)
4. 4
   Другоеdried at 50° C. under reduced pressure (0.067 kPa)

Методика

The procedure is similar to that described in Example 1, but starting with benzoic acid (11 g), N,N'carbonyldiimidazole (16.2 g) and 2-amino-7-(4-methoxyphenoxy)-1,8-naphthyridine (26.7 g). The product produced by precipitation in water (30.8 g; m.p. approximately 110° C.) is dissolved in boiling acetonitrile (150 cc). After 3 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (2×5 cc) and dried at 50° C. under reduced pressure (0.067 kPa). N-[7-(4-methoxyphenoxy)-1,8-naphthyridin-2-yl]benzamide (24.7 g) is produced, m.p. 171° C. 2-Amino-7-(4-methoxyphenoxy)-1,8-naphthyridine can be prepared in the following manner:

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